diff --git a/docs/release-notes/version-2.10.md b/docs/release-notes/version-2.10.md
index bc3d0e1a5..f42522194 100644
--- a/docs/release-notes/version-2.10.md
+++ b/docs/release-notes/version-2.10.md
@@ -10,6 +10,7 @@
 * [#5718](https://github.com/netbox-community/netbox/issues/5718) - Fix bulk editing of services when no port(s) are defined
 * [#5735](https://github.com/netbox-community/netbox/issues/5735) - Ensure consistent treatment of duplicate IP addresses
 * [#5738](https://github.com/netbox-community/netbox/issues/5738) - Fix redirect to device components view after disconnecting a cable
+* [#5841](https://github.com/netbox-community/netbox/issues/5841) - Disallow the creation of available prefixes/IP addresses in violation of assigned permission constraints
 
 ---
 
diff --git a/netbox/ipam/api/views.py b/netbox/ipam/api/views.py
index c322c249d..16db8f04f 100644
--- a/netbox/ipam/api/views.py
+++ b/netbox/ipam/api/views.py
@@ -1,4 +1,6 @@
 from django.conf import settings
+from django.core.exceptions import ObjectDoesNotExist, PermissionDenied
+from django.db import transaction
 from django.shortcuts import get_object_or_404
 from django_pglocks import advisory_lock
 from drf_yasg.utils import swagger_auto_schema
@@ -162,7 +164,12 @@ class PrefixViewSet(CustomFieldModelViewSet):
 
             # Create the new Prefix(es)
             if serializer.is_valid():
-                serializer.save()
+                try:
+                    with transaction.atomic():
+                        created = serializer.save()
+                        self._validate_objects(created)
+                except ObjectDoesNotExist:
+                    raise PermissionDenied()
                 return Response(serializer.data, status=status.HTTP_201_CREATED)
 
             return Response(serializer.errors, status=status.HTTP_400_BAD_REQUEST)
@@ -225,7 +232,12 @@ class PrefixViewSet(CustomFieldModelViewSet):
 
             # Create the new IP address(es)
             if serializer.is_valid():
-                serializer.save()
+                try:
+                    with transaction.atomic():
+                        created = serializer.save()
+                        self._validate_objects(created)
+                except ObjectDoesNotExist:
+                    raise PermissionDenied()
                 return Response(serializer.data, status=status.HTTP_201_CREATED)
 
             return Response(serializer.errors, status=status.HTTP_400_BAD_REQUEST)