diff --git a/netbox/core/apps.py b/netbox/core/apps.py
index b1337c7ed..f74a01aa9 100644
--- a/netbox/core/apps.py
+++ b/netbox/core/apps.py
@@ -19,6 +19,7 @@ class CoreConfig(AppConfig):
 
     def ready(self):
         from core.api import schema  # noqa: F401
+        from core.checks import check_duplicate_indexes  # noqa: F401
         from netbox.models.features import register_models
         from . import data_backends, events, search  # noqa: F401
         from netbox import context_managers  # noqa: F401
diff --git a/netbox/core/checks.py b/netbox/core/checks.py
new file mode 100644
index 000000000..cab52a025
--- /dev/null
+++ b/netbox/core/checks.py
@@ -0,0 +1,41 @@
+from django.core.checks import Error, register, Tags
+from django.db.models import Index, UniqueConstraint
+from django.apps import apps
+
+__all__ = (
+    'check_duplicate_indexes',
+)
+
+
+@register(Tags.models)
+def check_duplicate_indexes(app_configs, **kwargs):
+    """
+    Check for an index which is redundant to a declared unique constraint.
+    """
+    errors = []
+
+    for model in apps.get_models():
+        if not (meta := getattr(model, "_meta", None)):
+            continue
+
+        index_fields = {
+            tuple(index.fields) for index in getattr(meta, 'indexes', [])
+            if isinstance(index, Index)
+        }
+        constraint_fields = {
+            tuple(constraint.fields) for constraint in getattr(meta, 'constraints', [])
+            if isinstance(constraint, UniqueConstraint)
+        }
+
+        # Find overlapping definitions
+        if duplicated := index_fields & constraint_fields:
+            for fields in duplicated:
+                errors.append(
+                    Error(
+                        f"Model '{model.__name__}' defines the same field set {fields} in both `Meta.indexes` and "
+                        f"`Meta.constraints`.",
+                        obj=model,
+                    )
+                )
+
+    return errors