diff --git a/CHANGELOG.md b/CHANGELOG.md
index b2a5445fe..02a2c7479 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,7 @@ v2.5.8 (FUTURE)
 
 ## Bug Fixes
 
+* [#2781](https://github.com/digitalocean/netbox/issues/2781) - Filtering sites by multiple regions
 * [#2923](https://github.com/digitalocean/netbox/issues/2923) - Provider filter form's site field should be blank by default
 
 ---
diff --git a/netbox/dcim/filters.py b/netbox/dcim/filters.py
index 96ecefafd..3e3200aa8 100644
--- a/netbox/dcim/filters.py
+++ b/netbox/dcim/filters.py
@@ -49,14 +49,14 @@ class SiteFilter(CustomFieldFilterSet, django_filters.FilterSet):
         choices=SITE_STATUS_CHOICES,
         null_value=None
     )
-    region_id = django_filters.NumberFilter(
-        method='filter_region',
-        field_name='pk',
+    region_id = django_filters.ModelMultipleChoiceFilter(
+        queryset=Region.objects.all(),
         label='Region (ID)',
     )
-    region = django_filters.CharFilter(
-        method='filter_region',
-        field_name='slug',
+    region = django_filters.ModelMultipleChoiceFilter(
+        field_name='region__slug',
+        queryset=Region.objects.all(),
+        to_field_name='slug',
         label='Region (slug)',
     )
     tenant_id = django_filters.ModelMultipleChoiceFilter(
@@ -513,14 +513,16 @@ class DeviceFilter(CustomFieldFilterSet):
     )
     name = NullableCharFieldFilter()
     asset_tag = NullableCharFieldFilter()
-    region_id = django_filters.NumberFilter(
-        method='filter_region',
-        field_name='pk',
+    region_id = django_filters.ModelMultipleChoiceFilter(
+        field_name='site__region__id',
+        queryset=Region.objects.all(),
+        to_field_name='id',
         label='Region (ID)',
     )
-    region = django_filters.CharFilter(
-        method='filter_region',
-        field_name='slug',
+    region = django_filters.ModelMultipleChoiceFilter(
+        field_name='site__region__slug',
+        queryset=Region.objects.all(),
+        to_field_name='slug',
         label='Region (slug)',
     )
     site_id = django_filters.ModelMultipleChoiceFilter(