diff --git a/base_requirements.txt b/base_requirements.txt
index f0f6cfe38..8ac516380 100644
--- a/base_requirements.txt
+++ b/base_requirements.txt
@@ -81,4 +81,4 @@ py-gfm
 
 # Extensive cryptographic library (fork of pycrypto)
 # https://github.com/Legrandin/pycryptodome
-pycryptodome
+pycryptodomex
diff --git a/netbox/secrets/api/views.py b/netbox/secrets/api/views.py
index ee2b87a1f..dd22c424a 100644
--- a/netbox/secrets/api/views.py
+++ b/netbox/secrets/api/views.py
@@ -1,6 +1,6 @@
 import base64
 
-from Crypto.PublicKey import RSA
+from Cryptodome.PublicKey import RSA
 from django.db.models import Count
 from django.http import HttpResponseBadRequest
 from rest_framework.exceptions import ValidationError
diff --git a/netbox/secrets/forms.py b/netbox/secrets/forms.py
index ed0f455c1..f9998e991 100644
--- a/netbox/secrets/forms.py
+++ b/netbox/secrets/forms.py
@@ -1,5 +1,5 @@
-from Crypto.Cipher import PKCS1_OAEP
-from Crypto.PublicKey import RSA
+from Cryptodome.Cipher import PKCS1_OAEP
+from Cryptodome.PublicKey import RSA
 from django import forms
 from taggit.forms import TagField
 
diff --git a/netbox/secrets/models.py b/netbox/secrets/models.py
index 6dcb5abee..5539bdb38 100644
--- a/netbox/secrets/models.py
+++ b/netbox/secrets/models.py
@@ -1,9 +1,9 @@
 import os
 import sys
 
-from Crypto.Cipher import AES, PKCS1_OAEP
-from Crypto.PublicKey import RSA
-from Crypto.Util import strxor
+from Cryptodome.Cipher import AES, PKCS1_OAEP
+from Cryptodome.PublicKey import RSA
+from Cryptodome.Util import strxor
 from django.conf import settings
 from django.contrib.auth.hashers import make_password, check_password
 from django.contrib.auth.models import Group, User
diff --git a/netbox/secrets/tests/test_models.py b/netbox/secrets/tests/test_models.py
index b3ba0cee1..b4e506a19 100644
--- a/netbox/secrets/tests/test_models.py
+++ b/netbox/secrets/tests/test_models.py
@@ -1,6 +1,6 @@
 import string
 
-from Crypto.PublicKey import RSA
+from Cryptodome.PublicKey import RSA
 from django.conf import settings
 from django.contrib.auth.models import User
 from django.core.exceptions import ValidationError
diff --git a/old_requirements.txt b/old_requirements.txt
index b3f7b3c47..924b3bf17 100644
--- a/old_requirements.txt
+++ b/old_requirements.txt
@@ -1,3 +1,4 @@
 django-rest-swagger
 psycopg2
 pycrypto
+pycryptodome
diff --git a/requirements.txt b/requirements.txt
index b467651cd..1395cba49 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -19,4 +19,4 @@ netaddr==0.7.19
 Pillow==6.2.0
 psycopg2-binary==2.8.3
 py-gfm==0.1.4
-pycryptodome==3.8.2
+pycryptodomex==3.8.2