diff --git a/docs/release-notes/version-2.8.md b/docs/release-notes/version-2.8.md
index e26450f2b..e92ca7286 100644
--- a/docs/release-notes/version-2.8.md
+++ b/docs/release-notes/version-2.8.md
@@ -4,6 +4,7 @@
 
 ### Enhancements
 
+* [#4869](https://github.com/netbox-community/netbox/issues/4869) - Allow global search by MAC address
 * [#4898](https://github.com/netbox-community/netbox/issues/4898) - Add MAC address search field to interfaces list
 * [#4899](https://github.com/netbox-community/netbox/issues/4899) - Add MAC address column to interfaces table
 
diff --git a/netbox/dcim/filters.py b/netbox/dcim/filters.py
index 8c24180bb..4504a9a01 100644
--- a/netbox/dcim/filters.py
+++ b/netbox/dcim/filters.py
@@ -741,13 +741,14 @@ class DeviceComponentFilterSet(django_filters.FilterSet):
     )
     tag = TagFilter()
 
-    def search(self, queryset, name, value):
+    def search(self, queryset, name, value, additional_fields):
         if not value.strip():
             return queryset
-        return queryset.filter(
-            Q(name__icontains=value) |
-            Q(description__icontains=value)
-        )
+        fields = ['name__icontains', 'description__icontains']
+        if additional_fields:
+            fields.extend(additional_fields)
+        query_fields = {field: value for field in fields}
+        return queryset.filter(Q(**query_fields, _connector=Q.OR))
 
 
 class ConsolePortFilterSet(BaseFilterSet, DeviceComponentFilterSet):
@@ -911,6 +912,10 @@ class InterfaceFilterSet(BaseFilterSet, DeviceComponentFilterSet):
             'wireless': queryset.filter(type__in=WIRELESS_IFACE_TYPES),
         }.get(value, queryset.none())
 
+    def search(self, queryset, name, value):
+        additional_fields = ['mac_address__icontains']
+        return super().search(queryset=queryset, name=name, value=value, additional_fields=additional_fields)
+
 
 class FrontPortFilterSet(BaseFilterSet, DeviceComponentFilterSet):
     cabled = django_filters.BooleanFilter(
diff --git a/netbox/netbox/views.py b/netbox/netbox/views.py
index 37a516409..acd3d2100 100644
--- a/netbox/netbox/views.py
+++ b/netbox/netbox/views.py
@@ -13,14 +13,14 @@ from circuits.filters import CircuitFilterSet, ProviderFilterSet
 from circuits.models import Circuit, Provider
 from circuits.tables import CircuitTable, ProviderTable
 from dcim.filters import (
-    CableFilterSet, DeviceFilterSet, DeviceTypeFilterSet, PowerFeedFilterSet, RackFilterSet, RackGroupFilterSet, SiteFilterSet,
+    CableFilterSet, DeviceFilterSet, DeviceTypeFilterSet, InterfaceFilterSet, PowerFeedFilterSet, RackFilterSet, RackGroupFilterSet, SiteFilterSet,
     VirtualChassisFilterSet,
 )
 from dcim.models import (
     Cable, ConsolePort, Device, DeviceType, Interface, PowerPanel, PowerFeed, PowerPort, Rack, RackGroup, Site, VirtualChassis
 )
 from dcim.tables import (
-    CableTable, DeviceTable, DeviceTypeTable, PowerFeedTable, RackTable, RackGroupTable, SiteTable,
+    CableTable, DeviceTable, DeviceTypeTable, InterfaceDetailTable, PowerFeedTable, RackTable, RackGroupTable, SiteTable,
     VirtualChassisTable,
 )
 from extras.models import ObjectChange, ReportResult
@@ -96,6 +96,15 @@ SEARCH_TYPES = OrderedDict((
         'table': DeviceTable,
         'url': 'dcim:device_list',
     }),
+    ('interface', {
+        'permission': 'dcim.view_interface',
+        'queryset': Interface.objects.prefetch_related(
+            'device', 'virtual_machine',
+        ),
+        'filterset': InterfaceFilterSet,
+        'table': InterfaceDetailTable,
+        'url': 'dcim:interface_list',
+    }),
     ('virtualchassis', {
         'permission': 'dcim.view_virtualchassis',
         'queryset': VirtualChassis.objects.prefetch_related('master').annotate(member_count=Count('members')),