item-0 at level 0: unspecified: group _root_
  item-1 at level 1: title: Risk factors associated with fai ... s: Results of a multi-country analysis
    item-2 at level 2: paragraph: Clara R. Burgert-Brucker, Kathry ... garet Baker, John Kraemer, Molly Brady
    item-3 at level 2: paragraph: Global Health Division, RTI Inte ... shington, DC, United States of America
    item-4 at level 2: section_header: Abstract
      item-5 at level 3: text: Achieving elimination of lymphat ... as at highest risk of failing pre-TAS.
    item-6 at level 2: section_header: Author summary
      item-7 at level 3: text: Achieving elimination of lymphat ... ine prevalence and/or lower elevation.
    item-8 at level 2: section_header: Introduction
      item-9 at level 3: text: Lymphatic filariasis (LF), a dis ... 8 countries remain endemic for LF [3].
      item-10 at level 3: text: The road to elimination as a pub ... t elimination be officially validated.
      item-11 at level 3: text: Pre-TAS include at least one sen ... me of day that blood can be taken [5].
      item-12 at level 3: text: When a country fails to meet the ... o ensure rounds of MDA are not missed.
      item-13 at level 3: text: This study aims to understand wh ... e of limited LF elimination resources.
    item-14 at level 2: section_header: Methods
      item-15 at level 3: text: This is a secondary data analysi ... rch; no ethical approval was required.
      item-16 at level 3: text: Building on previous work, we de ... available global geospatial data sets.
      item-17 at level 3: table with [18x8]
        item-17 at level 4: caption: Table 1 Categorization of potential factors influencing pre-TAS results.
      item-18 at level 3: section_header: Data sources
        item-19 at level 4: text: Information on baseline prevalen ...  publicly available sources (Table 1).
      item-20 at level 3: section_header: Outcome and covariate variables
        item-21 at level 4: text: The outcome of interest for this ... r than or equal to 1% Mf or 2% Ag [4].
        item-22 at level 4: text: Potential covariates were derive ... is and the final categorizations used.
        item-23 at level 4: section_header: Baseline prevalence
          item-24 at level 5: text: Baseline prevalence can be assum ... (2) using the cut-off of <10% or ≥10%.
        item-25 at level 4: section_header: Agent
          item-26 at level 5: text: In terms of differences in trans ... dazole (DEC-ALB)] from the MDA domain.
        item-27 at level 4: section_header: Environment
          item-28 at level 5: text: LF transmission intensity is inf ... dicates a higher level of “greenness.”
          item-29 at level 5: text: We included the socio-economic v ...  proxy for socio-economic status [33].
          item-30 at level 5: text: Finally, all or parts of distric ... s were co-endemic with onchocerciasis.
        item-31 at level 4: section_header: MDA
          item-32 at level 5: text: Treatment effectiveness depends  ... esent a threat to elimination [41,42].
          item-33 at level 5: text: We considered three approaches w ... unds ever documented in that district.
        item-34 at level 4: section_header: Pre-TAS implementation
          item-35 at level 5: text: Pre-TAS results can be influence ... d throughout the time period of study.
      item-36 at level 3: section_header: Data inclusion criteria
        item-37 at level 4: text: The dataset, summarized at the d ... al analysis dataset had 554 districts.
      item-38 at level 3: section_header: Statistical analysis and modeling
        item-39 at level 4: text: Statistical analysis and modelin ... d the number of variables accordingly.
        item-40 at level 4: text: Sensitivity analysis was perform ... ot have been truly LF-endemic [43,44].
    item-41 at level 2: section_header: Results
      item-42 at level 3: text: The overall pre-TAS pass rate fo ... ts had baseline prevalences below 20%.
      item-43 at level 3: picture
        item-43 at level 4: caption: Fig 1 Number of pre-TAS by country.
      item-44 at level 3: picture
        item-44 at level 4: caption: Fig 2 District-level baseline prevalence by country.
      item-45 at level 3: text: Fig 3 shows the unadjusted analy ... overage, and sufficient rounds of MDA.
      item-46 at level 3: picture
        item-46 at level 4: caption: Fig 3 Percent pre-TAS failure by each characteristic (unadjusted).
      item-47 at level 3: text: The final log-binomial model inc ... igh baseline and diagnostic test used.
      item-48 at level 3: text: Fig 4 shows the risk ratio resul ... of failing pre-TAS (95% CI 1.95–4.83).
      item-49 at level 3: picture
        item-49 at level 4: caption: Fig 4 Adjusted risk ratios for pre-TAS failure with 95% Confidence Interval from log-binomial model.
      item-50 at level 3: text: Sensitivity analyses were conduc ... gnified by large confidence intervals.
      item-51 at level 3: table with [11x6]
        item-51 at level 4: caption: Table 2 Adjusted risk ratios for pre-TAS failure from log-binomial model sensitivity analysis.
      item-52 at level 3: text: Overall 74 districts in the data ... or 51% of all the failures (38 of 74).
      item-53 at level 3: picture
        item-53 at level 4: caption: Fig 5 Analysis of failures by model combinations.
    item-54 at level 2: section_header: Discussion
      item-55 at level 3: text: This paper reports for the first ... ctors associated with TAS failure [7].
      item-56 at level 3: text: Though diagnostic test used was  ...  FTS was more sensitive than ICT [45].
      item-57 at level 3: text: Elevation was the only environme ... ich impact vector chances of survival.
      item-58 at level 3: text: The small number of failures ove ... search has shown the opposite [15,16].
      item-59 at level 3: text: All other variables included in  ... are not necessary to lower prevalence.
      item-60 at level 3: text: Limitations to this study includ ...  reducing LF prevalence [41,48,51–53].
      item-61 at level 3: text: Fourteen districts were excluded ... ta to extreme outliners in a district.
      item-62 at level 3: text: As this analysis used data acros ... of individuals included in the survey.
      item-63 at level 3: text: This paper provides evidence fro ... th high baseline and/or low elevation.
    item-64 at level 2: section_header: Acknowledgments
      item-65 at level 3: text: The authors would like to thank  ... e surveys financially and technically.
    item-66 at level 2: section_header: References
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  item-121 at level 1: caption: Table 1 Categorization of potential factors influencing pre-TAS results.
  item-122 at level 1: caption: Fig 1 Number of pre-TAS by country.
  item-123 at level 1: caption: Fig 2 District-level baseline prevalence by country.
  item-124 at level 1: caption: Fig 3 Percent pre-TAS failure by each characteristic (unadjusted).
  item-125 at level 1: caption: Fig 4 Adjusted risk ratios for p ... ence Interval from log-binomial model.
  item-126 at level 1: caption: Table 2 Adjusted risk ratios for ... g-binomial model sensitivity analysis.
  item-127 at level 1: caption: Fig 5 Analysis of failures by model combinations.